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Benjamin Walter, Ph.D.

  • Assistant Professor, Biomedical Engineering
  • 1080 Carmack Road
    Columbus, OH 43210

About

Dr. Benjamin Walter is a Post-Doctural Researcher in the Spine Research Institute. Within the SRI, Ben’s research focuses on how changes in intervertebral disc biomechanics, which occur with disease, influence the cellular response to physiologic loading. He received his PhD in Biomedical Engineering from The City College of New York and conducted his doctoral research at the Icahn School of Medicine at Mount Sinai in New York City.  Ben received his B.S. (2008) and M.S. (2010) in Biomedical Engineering from Rose-Hulman Institute of Technology and the University of Vermont, respectively. His background is in whole IVD organ culture and cell culture models of intervertebral disc degeneration, with an emphasis on how inflammation contributes to altered disc mechanical behavior and mechanotransduction.

Journal Articles

2018

  • Le, P.; Aurand, A.; Walter, B.A.; Best, T.M. et al., 2018, "Development of a lumbar EMG-based coactivation index for the assessment of complex dynamic tasks.." Ergonomics 61, no. 3, 381-389 - 381-389.
  • Nakazawa, K.R.; Walter, B.A.; Laudier, D.M.; Krishnamoorthy, D. et al., 2018, "Accumulation and localization of macrophage phenotypes with human intervertebral disc degeneration.." Spine J 18, no. 2, 343-356 - 343-356.

2015

  • Walter, B.A.; Torre, O.M.; Laudier, D.; Naidich, T.P. et al., 2015, "Form and function of the intervertebral disc in health and disease: a morphological and stain comparison study.." J Anat 227, no. 6, 707-716 - 707-716.
  • Walter, B.A.; Likhitpanichkul, M.; Illien-Junger, S.; Roughley, P.J. et al., 2015, "TNFα transport induced by dynamic loading alters biomechanics of intact intervertebral discs.." PLoS One 10, no. 3, e0118358 - e0118358.
  • Walter, B.A.; Purmessur, D.; Likhitpanichkul, M.; Weinberg, A. et al., 2015, "Inflammatory Kinetics and Efficacy of Anti-inflammatory Treatments on Human Nucleus Pulposus Cells.." Spine (Phila Pa 1976) 40, no. 13, 955-963 - 955-963.

2014

  • Illien-Jünger,Svenja; Lu,Young; Purmessur,Devina; Mayer,Jillian,E; Walter,Benjamin,A; Roughley,Peter,J; Qureshi,Sheeraz,A; Hecht,Andrew,C; Iatridis,James,C, 2014, "Detrimental effects of discectomy on intervertebral disc biology can be decelerated by growth factor treatment during surgery: a large animal organ culture model.." spine journal 14, no. 11, 2724-2732 - 2724-2732.
  • Walter,B,A; Illien-Jünger,S; NASSER,P,R; Hecht,A,C; Iatridis,J,C, 2014, "Development and validation of a bioreactor system for dynamic loading and mechanical characterization of whole human intervertebral discs in organ culture.." Journal of biomechanics 47, no. 9, 2095-2101 - 2095-2101.
  • Walter, B.A.; Illien-Jünger, S.; Nasser, P.R.; Hecht, A.C. et al., 2014, "Development and validation of a bioreactor system for dynamic loading and mechanical characterization of whole human intervertebral discs in organ culture.." J Biomech 47, no. 9, 2095-2101 - 2095-2101.
  • Likhitpanichkul, M.; Dreischarf, M.; Illien-Junger, S.; Walter, B.A. et al., 2014, "Fibrin-genipin adhesive hydrogel for annulus fibrosus repair: performance evaluation with large animal organ culture, in situ biomechanics, and in vivo degradation tests.." Eur Cell Mater 28, 25-37 - 25-37.
  • Illien-Jünger, S.; Lu, Y.; Purmessur, D.; Mayer, J.E. et al., 2014, "Detrimental effects of discectomy on intervertebral disc biology can be decelerated by growth factor treatment during surgery: a large animal organ culture model.." Spine J 14, no. 11, 2724-2732 - 2724-2732.
  • Illien-Juenger,Svenja; Lu,Young; Purmessur,Devina; Mayer,Jillian,E; Walter,Benjamin,A; Roughley,Peter,J; Qureshi,Sheeraz,A; Hecht,Andrew,C; Iatridis,James,C, 2014, "Detrimental effects of discectomy on intervertebral disc biology can be decelerated by growth factor treatment during surgery: a large animal organ culture model." SPINE JOURNAL 14, no. 11, 2724-2732 - 2724-2732.

2013

  • Purmessur, D.; Walter, B.A.; Roughley, P.J.; Laudier, D.M. et al., 2013, "A role for TNFα in intervertebral disc degeneration: a non-recoverable catabolic shift.." Biochem Biophys Res Commun 433, no. 1, 151-156 - 151-156.
  • Iatridis, J.C.; Nicoll, S.B.; Michalek, A.J.; Walter, B.A. et al., 2013, "Role of biomechanics in intervertebral disc degeneration and regenerative therapies: what needs repairing in the disc and what are promising biomaterials for its repair?." Spine J 13, no. 3, 243-262 - 243-262.
  • Purmessur,D; Walter,B,A; Roughley,P,J; Laudier,D,M; Hecht,A,C; Iatridis,James, 2013, "A role for TNF alpha in intervertebral disc degeneration: A non-recoverable catabolic shift." BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 433, no. 1, 151-156 - 151-156.

2011

  • Walter, B.A.; Korecki, C.L.; Purmessur, D.; Roughley, P.J. et al., 2011, "Complex loading affects intervertebral disc mechanics and biology.." Osteoarthritis Cartilage 19, no. 8, 1011-1018 - 1011-1018.
  • Walter,B,A; Korecki,C,L; Purmessur,D; Roughley,P,J; Michalek,A,J; Iatridis,J,C, 2011, "Complex loading affects intervertebral disc mechanics and biology." OSTEOARTHRITIS AND CARTILAGE 19, no. 8, 1011-1018 - 1011-1018.

Unknown

  • Likhitpanichkul, M.; Torre, O.M.; Gruen, J.; Walter, B.A. et al., "Do mechanical strain and TNF-α interact to amplify pro-inflammatory cytokine production in human annulus fibrosus cells?." J Biomech 49, no. 7, 1214-1220 - 1214-1220.
  • Walter, B.A.; Mageswaran, P.; Mo, X.; Boulter, D.J. et al., "MR Elastography-derived Stiffness: A Biomarker for Intervertebral Disc Degeneration.." Radiology 285, no. 1, 167-175 - 167-175.
  • Walter BA, Purmessur D, Likhitpanichkul M, Weinberg A, Cho SK, Qureshi SA, Hecht AC, Iatridis JC, Inflammatory Kinetics and Efficacy of Anti-inflammatory Treatments on Human Nucleus Pulpous Cells. Spine